Chronic Sclerosing Sialoadenitis as a Manifestation of IgG4-Associated Disease

The article presents an analytical review of scientifi c domestic and foreign literature over the past
15 years, devoted to the pathogenesis and diagnosis of IgG4-associated disease (IgG4-AD). This
is a new nosological unit what combines several pathological conditions. Is a systemic immunemediated
disease, which may involve the salivary glands, pancreas, liver, retroperitoneal space,
biliary tract, salivary glands, orbit, lungs, kidneys, which manifests itself as tumor-like organ damage,
increase serum IgG4 level and the formation of severe fi brosis and lymphoplasmocytic infi ltrate
in tissues with a high content of IgG4-positive plasma cells. The main aspects of the etiology,
pathogenetic mechanisms and diagnosis of IgG4-AD are highlighted.